Our Research

Carbon Dot based nanostructures for visual detection of DNA damage lesions and G Quadruplex

Carbon Dot-DNA aptamer hybrid nanostructure for visual detection of food borne toxins

We explore nanotechnology based detection of DNA damage lesions with particular emphasis on visual detection strategies. We also developed a biosensing platform for visual detection of G-Quadruplex conformation in DNA. Fluorescent Carbon Dots are being used for such detection.

Aptasensing platform are being researched as a capable substituent for antibody based detection . We study aptamer-Carbon dot hybrid nanoassembly for visual detection of toxins. Visual detection ensures that no equipment is required for the detection and point of care biosensing could be achieved.

Carbon Dot-DNA hybrid hydrogel for drug delivery

DNA based hydrogel are biocompatible and may be equipped with targeting entities for sustained release of drugs. We study DNA-carbon dot hydrogels that  could give additional advantage of drug tracking.

Quantum Dot-DNA hybrid nanoassembly for Photodynamic Therapy (PDT)

Aqueous soluble non toxic quantum dot (QD) can act as FRET donors to photosensitizers for generation of ROS in PDT. Moreover, QD offer surface modification for conjugation with DNA that self assemble to create interesting nanoassembly for targeted PDT applications.

Mechanistic study of repair of Multicomponent Clustered DNA damage

Closely located multiple damaged lesions in DNA give to repair resistant clustered DNA damage that are inherently linked to mutagenesis and carcinogenesis. We study the repair and processing of the lesions to derive valuable information regarding the hierarchical repair process of complex clusters in DNA.

DNA-Organic hybrid Nanostructures for drug delivery and other biomedical applications

Self-assembled DNA-organic nanostructures are attractive options for drug delivery, antimicrobial coating, photodynamic therapy and others. We have successfully designed many such hybrids for interesting biomedical applications. Such structures are thermally reversible and completely biocompatible.